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Medical management of invasive fungal infections of the central nervous system in pediatric cancer patients.

Authors
Type
Published Article
Journal
Pediatric Blood & Cancer
1545-5017
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
62
Issue
6
Pages
1095–1098
Identifiers
DOI: 10.1002/pbc.25331
PMID: 25407593
Source
Medline
Keywords
  • Aspergillus
  • Cancer
  • Central Nervous System
  • Pediatric Fungal Infection
  • Rhizopus

Abstract

Fungal infections of the central nervous system (CNS) are associated with high mortality rates in immunocompromised patients. Surgical intervention is a mainstay of therapy, but not always possible. We describe the use of medical therapy for the treatment of CNS fungal infections in four pediatric cancer patients. Definitive resection was not performed in any patient. All patients initially received combination antifungal therapy with good clinical response; long-term survival was documented in two patients able to transition to long-term azole therapy. Prolonged antifungal therapy is an important option for treating invasive CNS fungal infections when surgery is not feasible.

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