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Mediators of multiple organ failure.

Authors
  • Goris, R J1
  • 1 Department of General Surgery, University Hospital St. Radboud, Nijmegen, The Netherlands. , (Netherlands)
Type
Published Article
Journal
Intensive Care Medicine
Publisher
Springer Science and Business Media LLC
Publication Date
Jan 01, 1990
Volume
16 Suppl 3
Identifiers
PMID: 2289989
Source
Medline
Language
English
License
Unknown

Abstract

Multiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germ-free animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome.

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