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Mediation of gonadotrophin-stimulated growth and differentiation of human granulosa cells by adenosine-3',5'-monophosphate: one molecule, two messages.

Authors
  • Yong, E L
  • Baird, D T
  • Hillier, S G
Type
Published Article
Journal
Clinical endocrinology
Publication Date
Jul 01, 1992
Volume
37
Issue
1
Pages
51–58
Identifiers
PMID: 1330383
Source
Medline
License
Unknown

Abstract

These results suggest that granulosa cell maturation in the follicular phase of the menstrual cycle (controlled by FSH) is associated with a low cyclic AMP tone that favours cell growth and expression of aromatase activity in the developing preovulatory follicle. During the early luteal phase (dominated by LH), the intracellular cycle AMP tone increases to allow maximal progesterone production and inhibition of cell growth in the corpus luteum. Thereby one second messenger can mediate divergent gonadotrophic effects on granulosa cell growth and differentiation in the human ovary.

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