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The Median Eminence, A New Oligodendrogenic Niche in the Adult Mouse Brain

Authors
  • Zilkha-Falb, Rina1
  • Kaushansky, Nathali1
  • Ben-Nun, Avraham1
  • 1 Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel
Type
Published Article
Journal
Stem Cell Reports
Publisher
Elsevier
Publication Date
May 14, 2020
Volume
14
Issue
6
Pages
1076–1092
Identifiers
DOI: 10.1016/j.stemcr.2020.04.005
PMID: 32413277
PMCID: PMC7355143
Source
PubMed Central
Keywords
License
Unknown

Abstract

Zilkha-Falb and colleagues show an enrichment of BrdU+ NG2+ cells in the median eminence (ME) of EAE mice. ME cells generate neurospheres differentiating to MBP+ OLs after transplantation to the LV of Shi mice. TSP1 inhibits oligodendrocyte differentiation of ME cells, corroborating its decreased expression in the ME of EAE mice. These findings suggest the ME as oligodendrogenic niche to increase OPCs under demyelination.

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