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Mechanochemical Organocatalysis: Do High Enantioselectivites Contradict what we Might Expect?

Authors
  • Williams, MTJ
  • Morrill, LC
  • Browne, DL
Publication Date
Jan 21, 2022
Source
UCL Discovery
Language
English
License
Unknown
External links

Abstract

Ball mills input energy to samples by pulverising the contents of the jar. Each impact on the sample or wall of the jar results in an instantaneous transmission of energy in the form of a temperature and pressure increase (volume reduction). Conversely, enantioselective organocatalytic reactions proceed through perceived delicate and well-organised transition states. Does there exist a dichotomy in the idea of enantioselective mechanochemical organocatalysis? This Review provides a survey of the literature reporting the combination of organocatalytic reactions with mechanochemical ball milling conditions. Where possible, direct comparisons of stirred in solution, stirred neat and ball milled processes are drawn with a particular focus on control of stereoselectivity.

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