[Mechanisms underlying thyroid hormone response gene regulation during amphibian development].
UMR5166 CNRS, USM-501 Muséum National d'Histoire Naturelle, Département Régulation Développement et Diversité Moléculaire, CP32, 7 rue Cuvier, 75231 Paris Cedex 05, France.
- Published Article
Journal de la Societe de biologie
- Publication Date
Jan 01, 2008
Amphibian metamorphosis is an excellent model to study the diverse effects of thyroid hormones (TH). TH modulate target gene expression via thyroid hormone receptors (TR). Generally, unliganded TR repress transcription, whereas liganded TR activate transcription. During metamorphosis, these dual effects of TR are evident. Moreover, we show that gene specific response to TH can underline the multiple effects of TH. Finally, studies of unliganded-thyroid hormone receptor function reveal a physiological role in eye development.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/18547503