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[Mechanisms underlying thyroid hormone response gene regulation during amphibian development].

Authors
  • 1
  • 1 UMR5166 CNRS, USM-501 Muséum National d'Histoire Naturelle, Département Régulation Développement et Diversité Moléculaire, CP32, 7 rue Cuvier, 75231 Paris Cedex 05, France. , (France)
Type
Published Article
Journal
Journal de la Societe de biologie
Publication Date
Volume
202
Issue
2
Pages
73–81
Identifiers
DOI: 10.1051/jbio:2008009
PMID: 18547503
Source
Medline
License
Unknown

Abstract

Amphibian metamorphosis is an excellent model to study the diverse effects of thyroid hormones (TH). TH modulate target gene expression via thyroid hormone receptors (TR). Generally, unliganded TR repress transcription, whereas liganded TR activate transcription. During metamorphosis, these dual effects of TR are evident. Moreover, we show that gene specific response to TH can underline the multiple effects of TH. Finally, studies of unliganded-thyroid hormone receptor function reveal a physiological role in eye development.

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