Affordable Access

Mechanisms of resistance to S. mansoni infection: the rat model.

Authors
  • Khalife, J
  • Cêtre, C
  • Pierrot, C
  • Capron, M
Type
Published Article
Journal
Parasitology international
Publication Date
Dec 01, 2000
Volume
49
Issue
4
Pages
339–345
Identifiers
PMID: 11077269
Source
Medline
License
Unknown

Abstract

Human schistosomiasis is associated with IgE and eosinophilia, feature of a type 2 response. In experimental investigations, murine model has been widely used in order to dissect the immune responses involved in the expression of protective immunity or disease in Schistosoma mansoni infection. Collectively, observations made in this model and in humans demonstrated a strong contrast since a Th2 response in infected mice is involved in the expression of pathology, however, in infected humans the same type of response is rather beneficial for the host. This review will consider the relevance of extrapolating studies of immune responses from experimentally infected rats a semi-permissive host, to studies on S. mansoni infected humans.

Report this publication

Statistics

Seen <100 times