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Mechanisms of repetitive transcranial magnetic stimulation for anti-depression: Evidence from preclinical studies.

Authors
  • Luan, Di1
  • Zhao, Ming-Ge2
  • Shi, Ya-Chen1
  • Li, Ling1
  • Cao, Yu-Jia1
  • Feng, Hai-Xia2
  • Zhang, Zhi-Jun1
  • 1 Department of Neurology, Affiliated Zhongda Hospital, Research Institution of Neuropsychiatry, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China. , (China)
  • 2 Department of Nursing, School of Medicine, Southeast University, Nanjing 210009, Jiangsu Province, China. , (China)
Type
Published Article
Journal
World journal of psychiatry
Publication Date
Oct 19, 2020
Volume
10
Issue
10
Pages
223–233
Identifiers
DOI: 10.5498/wjp.v10.i10.223
PMID: 33134113
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

This review summarizes the anti-depressant mechanisms of repetitive transcranial magnetic stimulation in preclinical studies, including anti-inflammatory effects mediated by activation of nuclear factor-E2-related factor 2 signaling pathway, anti-oxidative stress effects, enhancement of synaptic plasticity and neurogenesis via activation of the endocannabinoid system and brain derived neurotrophic factor signaling pathway, increasing the content of monoamine neurotransmitters via inhibition of Sirtuin 1/monoamine oxidase A signaling pathway, and reducing the activity of the hypothalamic-pituitary-adrenocortical axis. We also discuss the shortcomings of transcranial magnetic stimulation in preclinical studies such as inaccurate positioning, shallow depth of stimulation, and difficulty in elucidating the neural circuit mechanism up- and down-stream of the stimulation target brain region. ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

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