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Mechanisms of Neural Crest Migration

Authors
  • Szabó, András
  • Mayor, Roberto
Type
Published Article
Journal
Annual Review of Genetics
Publisher
Annual Reviews
Publication Date
Nov 23, 2018
Volume
52
Pages
43–63
Identifiers
DOI: 10.1146/annurev-genet-120417-031559
Source
Annual Reviews
Keywords
License
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Abstract

Neural crest cells are a transient embryonic cell population that migrate collectively to various locations throughout the embryo to contribute a number of cell types to several organs. After induction, the neural crest delaminates and undergoes an epithelial-to-mesenchymal transition before migrating through intricate yet characteristic paths. The neural crest exhibits a variety of migratory behaviors ranging from sheet-like mass migration in the cephalic regions to chain migration in the trunk. During their journey, neural crest cells rely on a range of signals both from their environment and within the migrating population for navigating through the embryo as a collective. Here we review these interactions and mechanisms, including chemotactic cues of neural crest cells’ migration.

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