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Mechanisms of improvement of respiratory failure in patients with COPD treated with NIV.

Authors
  • Nickol, Annabel H1
  • Hart, Nicholas
  • Hopkinson, Nicholas S
  • Hamnegård, Carl-Hugo
  • Moxham, John
  • Simonds, Anita
  • Polkey, Michael I
  • 1 Respiratory Muscle Laboratory, Royal Brompton Hospital, London, UK. [email protected]
Type
Published Article
Journal
International journal of chronic obstructive pulmonary disease
Publication Date
Jan 01, 2008
Volume
3
Issue
3
Pages
453–462
Identifiers
PMID: 18990974
Source
Medline
License
Unknown

Abstract

These findings suggest decreased gas trapping and increased ventilatory sensitivity to CO2 are the principal mechanism underlying improvements in gas-exchange in patients with COPD following NIV. Changes in some volitional but not nonvolitional muscle strength measures may reflect improved patient effort.

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