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Mechanisms of immune suppression by myeloid-derived suppressor cells: the role of interleukin-10 as a key immunoregulatory cytokine

  • Yaseen, Mahmoud Mohammad1
  • Abuharfeil, Nizar Mohammad1
  • Darmani, Homa2
  • Daoud, Ammar3
  • 1 Department of Biotechnology and Genetic Engineering, Jordan University of Science and Technology, Irbid 22110 , (Jordan)
  • 2 Department of Applied Biology, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid 22110 , (Jordan)
  • 3 Department of Internal Medicine, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110 , (Jordan)
Published Article
Open Biology
The Royal Society
Publication Date
Sep 16, 2020
DOI: 10.1098/rsob.200111
PMID: 32931721
PMCID: PMC7536076
PubMed Central


Chronic immune activation and inflammation are unwanted consequences of many pathological conditions, since they could lead to tissue damage and immune exhaustion, both of which can worsen the pathological condition status. In fact, the immune system is naturally equipped with immunoregulatory cells that can limit immune activation and inflammation. However, chronic activation of downregulatory immune responses is also associated with unwanted consequences that, in turn, could lead to disease progression as seen in the case of cancer and chronic infections. Myeloid-derived suppressor cells (MDSCs) are now considered to play a pivotal role in the pathogenesis of different inflammatory pathological conditions, including different types of cancer and chronic infections. As a potent immunosuppressor cell population, MDSCs can inhibit specific and non-specific immune responses via different mechanisms that, in turn, lead to disease persistence. One such mechanism by which MDSCs can activate their immunosuppressive effects is accomplished by secreting copious amounts of immunosuppressant molecules such as interleukin-10 (IL-10). In this article, we will focus on the pathological role of MDSC expansion in chronic inflammatory conditions including cancer, sepsis/infection, autoimmunity, asthma and ageing, as well as some of the mechanisms by which MDSCs/IL-10 contribute to the disease progression in such conditions.

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