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Mechanisms of Human Immunodeficiency Virus-Associated Lymphocyte Regulated Cell Death.

Authors
  • Paim, Ana C1
  • Badley, Andrew D1, 2
  • Cummins, Nathan W1
  • 1 Division of Infectious Diseases, Mayo Clinic, Rochester, Minnesota.
  • 2 Department of Molecular Medicine, Mayo Clinic, Rochester, Minnesota.
Type
Published Article
Journal
AIDS Research and Human Retroviruses
Publisher
Mary Ann Liebert
Publication Date
Dec 10, 2019
Identifiers
DOI: 10.1089/AID.2019.0213
PMID: 31659912
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Human immunodeficiency virus-1 (HIV-1) causes CD4 T cell depletion through a number of mechanisms, including programmed cell death pathways (both apoptotic and nonapoptotic). In the setting of HIV-1 infection, the enhanced lymphocyte cell death occurs as a consequence of complex interactions between the host immune system and viral factors, which are reviewed herein. On the other hand, the main challenge to HIV-1 eradication is the development of latent infection in a subset of long lived cells, including CD4+ T cells and macrophages, which resist HIV-induced cell death. Understanding the potential mechanisms of how HIV-1 induces lymphocyte cell death is critical to the "kick and kill" cure strategy, which relies on the effective killing of reactivated, HIV-1-infected cells.

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