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Mechanisms of hemodynamic actions of furosemide: differentiation of vascular and renal effects on blood pressure in functionally anephric hypertensive patients.

Authors
  • Mukherjee, S K
  • Katz, M A
  • Michael, U F
  • Ogden, D A
Type
Published Article
Journal
American Heart Journal
Publisher
Elsevier
Publication Date
Mar 01, 1981
Volume
101
Issue
3
Pages
313–318
Identifiers
PMID: 7468438
Source
Medline
License
Unknown

Abstract

To differentiate diuretic and direct cardiocirculatory properties of furosemide for elucidation of the vasodepressor mechanisms of action of the agent in the acute treatment of hypertension, the peripheral vascular effects of intravenous furosemide (3 mg/kg) on supine blood pressure (BP) and forearm hemodynamics in 11 functionally anephric hypertensive patients (creatinine clearance less than 2 ml/min) were studied. BP was recorded by sphygmomanometer and forearm hemodynamics were measured by strain gauge plethysmography. While diastolic BP decreased only 2.7 mm Hg at 30 minutes, forearm blood flow increased 55% (p less than 0.01) mediated by decreased peripheral vascular resistance of 30% (p less than 0.01) at 15 minutes which dissipated by 30 minutes. Systolic BP, indices of venous capacity, weight, hematocrit, serum electrolytes, and plasma renin activity were unchanged. No diuresis occurred. It is concluded that the early hypotensive effect of furosemide depends upon diuresis.

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