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Mechanisms of HCV-induced liver cancer: What did we learn from in vitro and animal studies?

Authors
  • Rusyn, Ivan
  • Lemon, Stanley M.1, 2, 3, 4, 2
  • 1 Department of Environmental Sciences & Engineering
  • 2 University of North Carolina
  • 3 Division of Infectious Diseases
  • 4 Department of Medicine
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jan 01, 2013
Volume
345
Issue
2
Pages
210–215
Identifiers
DOI: 10.1016/j.canlet.2013.06.028
Source
Elsevier
Keywords
License
Unknown

Abstract

Hepatitis C virus (HCV) is a cause of liver diseases that range from steatohepatitis, to fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). The challenge of understanding the pathogenesis of HCV-associated liver cancer is difficult as most standard animal models used in biomedical research are not permissive to HCV infection. Herein, we provide an overview of a number of creative in vivo, mostly in the mouse, and in vitro models that have been developed to advance our understanding of the molecular and cellular effects of HCV on the liver, specifically with their relevance to HCC.

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