Affordable Access

[The mechanisms of the ethomersol correction of postischemic hypoperfusion].

Authors
  • Plotnikova, T M
  • Kulakova, Z V
  • Smol'iakova, V I
  • Plotnikov, M B
Type
Published Article
Journal
Eksperimental'naia i klinicheskaia farmakologiia
Publication Date
Jan 01, 1992
Volume
55
Issue
4
Pages
11–13
Identifiers
PMID: 1458175
Source
Medline
License
Unknown

Abstract

In rat experiments during brain ischemia (30-min carotid artery occlusion), ethomersol administered intraperitoneally in a dose of 50 mg/kg before occlusion or at the end of ischemia eliminated postischemic hypoperfusion. The effect of the drug was due to its spasmolytic and antiaggregatory activities. An analysis of the vasodilating action of ethomersol revealed its capacity to block potential-dependent calcium channels and partially intracellular calcium mobilization when the adrenergic and serotoninergic receptors were activated. The antiaggregatory activity of the drug appeared as inhibited platelet aggregation, which was induced by ADP, serotonin, arachidonic acid, thrombin, and as enhanced antiaggregatory activity of the vascular wall.

Report this publication

Statistics

Seen <100 times