Affordable Access

deepdyve-link
Publisher Website

Mechanisms of epidermal growth factor receptor signaling as characterized by patterned ligand activation and mutational analysis.

Authors
  • Holowka, David1
  • Baird, Barbara2
  • 1 Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: [email protected]
  • 2 Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Type
Published Article
Journal
Biochimica et Biophysica Acta (BBA) - Biomembranes
Publisher
Elsevier
Publication Date
Sep 01, 2017
Volume
1859
Issue
9 Pt A
Pages
1430–1435
Identifiers
DOI: 10.1016/j.bbamem.2016.12.015
PMID: 28024796
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The cell surface receptor for epidermal growth factor (EGFR), a receptor tyrosine kinase, is a key player in normal cell growth and proliferation. Mutations in this receptor often lead to oncological transformation and other pathologies. Because of its representation of the receptor tyrosine kinase family and its important role in health and disease, a broad range of studies have been carried out in many laboratories to investigate the structural basis for transmembrane receptor activation and the resulting assembly of cytosolic signaling components. This review highlights two approaches our laboratory has taken to gain more detailed information about both aspects: Surface patterned ligands to examine recruitment of the signaling machinery, and mutational analysis to examine the regulatory role of EGFR's juxtamembrane segment. This article is part of a Special Issue entitled: Interactions between membrane receptors in cellular membranes edited by Kalina Hristova. Copyright © 2016 Elsevier B.V. All rights reserved.

Report this publication

Statistics

Seen <100 times