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Mechanisms of eosinophil accumulation around eggs of Schistosoma japonicum: role of two purified components, allergen and eosinophil chemotactic factor, from soluble egg antigens measured on sensitized guinea pig skin.

Authors
  • Horii, Y1
  • Owhashi, M
  • Ishii, A
  • 1 Department of Medical Zoology, Nagasaki University School of Medicine, Japan. , (Japan)
Type
Published Article
Journal
Parasitology research
Publication Date
Jan 01, 1990
Volume
76
Issue
7
Pages
602–605
Identifiers
PMID: 2217121
Source
Medline
License
Unknown

Abstract

Mechanisms of eosinophil response induced by soluble egg antigen (SEA) in Schistosoma japonicum-infected guinea pig tissues were analyzed using two purified components of SEA: major allergenic components (JEAL) and a major eosinophil chemotactic component (ECF-SjE). Eosinophil response to the crude SEA of S. japonicum was detected at the injection site mainly at 2-8 h after the antigenic challenge; this response consisted of two different phases of eosinophil attraction. An early phase (2 h) was mediated by an immediate-type hypersensitivity reaction; JEAL played an important role in mediating this phase of eosinophil response. A late phase (8 h) was mediated by ECF-SjE. Therefore, this phase of eosinophil response was caused by direct eosinophilotactic activity of SEA. These two types of eosinophil response must be important processes in the formation of S. japonicum egg-associated eosinophilic granuloma.

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