Affordable Access

deepdyve-link
Publisher Website

Mechanisms of Autophagy in Metabolic Stress Response.

Authors
  • Gross, Angelina S1
  • Graef, Martin2
  • 1 Max Planck Institute for Biology of Ageing, Cologne, Germany. , (Germany)
  • 2 Max Planck Institute for Biology of Ageing, Cologne, Germany; CECAD, University of Cologne, Cologne, Germany. Electronic address: [email protected] , (Germany)
Type
Published Article
Journal
Journal of Molecular Biology
Publisher
Elsevier
Publication Date
Oct 15, 2019
Identifiers
DOI: 10.1016/j.jmb.2019.09.005
PMID: 31626805
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Autophagy is a highly conserved catabolic pathway critical for stress responses and the maintenance of cellular homeostasis. Defective autophagy contributes to the etiology of an increasing number of diseases including cancer, neurodegeneration, and diabetes. Cells have to integrate complex metabolic information in order to counteract metabolic challenges ranging from carbon, nitrogen, and phosphate to metal ion limitations. An unparalleled variety of cytoplasmic materials in size and nature can be transported into the lytic compartment for degradation and recycling by transient double-membrane compartments, termed autophagosomes, during macroautophagy. In this review, we will outline our current mechanistic understanding of how cells regulate the initiation of macroautophagy to target substrates nonselectively or selectively. With an emphasis on findings in the yeast system, we will describe the emerging principles underlying the regulation of autophagy substrate recognition, which critically shapes the scope of stress-adapted autophagy responses upon diverse metabolic challenges. Copyright © 2019 Elsevier Ltd. All rights reserved.

Report this publication

Statistics

Seen <100 times