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Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.

Authors
  • Cao, Bing-Qian1
  • Tan, Feng1
  • Zhan, Jie2
  • Lai, Peng-Hui3
  • 1 Department of Neurology, Foshan Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Foshan, Guangdong Province, China. , (China)
  • 2 Department of Rehabilitation, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong Province, China. , (China)
  • 3 Department of Rehabilitation, Nan'ao People's Hospital Dapeng New District, Shenzhen, Guangdong Province, China. , (China)
Type
Published Article
Journal
Neural Regeneration Research
Publisher
Medknow Publications
Publication Date
May 01, 2021
Volume
16
Issue
5
Pages
944–954
Identifiers
DOI: 10.4103/1673-5374.297061
PMID: 33229734
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair. After cerebral ischemia/reperfusion, microglia are activated, and a large number of circulating inflammatory cells infiltrate the affected area. This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage, including neuron necrosis, blood-brain barrier destruction, cerebral edema, and an oxidative stress response. Activation of inflammatory signaling pathways plays a key role in the pathological process of ischemic stroke. Increasing evidence suggests that acupuncture can reduce the inflammatory response after cerebral ischemia/reperfusion and promote repair of the injured nervous system. Acupuncture can not only inhibit the activation and infiltration of inflammatory cells, but can also regulate the expression of inflammation-related cytokines, balance the effects of pro-inflammatory and anti-inflammatory factors, and interfere with inflammatory signaling pathways. Therefore, it is important to study the transmission and regulatory mechanism of inflammatory signaling pathways after acupuncture treatment for cerebral ischemia/reperfusion injury to provide a theoretical basis for clinical treatment of this type of injury using acupuncture. Our review summarizes the overall conditions of inflammatory cells, mediators, and pathways after cerebral ischemia/reperfusion, and discusses the possible synergistic intervention of acupuncture in the inflammatory signaling pathway network to provide a foundation to explore the multiple molecular mechanisms by which acupuncture promotes nerve function restoration.

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