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Mechanism of MRX inhibition by Rif2 at telomeres

Authors
  • Roisné-Hamelin, Florian1
  • Pobiega, Sabrina1
  • Jézéquel, Kévin1
  • Miron, Simona2
  • Dépagne, Jordane3
  • Veaute, Xavier3
  • Busso, Didier3
  • Du, Marie-Hélène Le2
  • Callebaut, Isabelle4
  • Charbonnier, Jean-Baptiste2
  • Cuniasse, Philippe2
  • Zinn-Justin, Sophie2
  • Marcand, Stéphane1
  • 1 iRCM, UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France , Fontenay-aux-Roses (France)
  • 2 Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France , Gif-sur-Yvette (France)
  • 3 UMR Stabilité Génétique Cellules Souches et Radiations, Fontenay-aux-Roses, France , Fontenay-aux-Roses (France)
  • 4 Institut de Minéralogie de Physique des Matériaux et de Cosmochimie (IMPMC), Paris, France , Paris (France)
Type
Published Article
Journal
Nature Communications
Publisher
Springer Nature
Publication Date
May 12, 2021
Volume
12
Issue
1
Identifiers
DOI: 10.1038/s41467-021-23035-w
Source
Springer Nature
License
Green

Abstract

Different proteins localised at telomeres ensure chromosome end stability to prevent double strand-end break recognition. Here the authors provide new insight into how in S. cerevisiae the interaction between Rif2 and Rad50 inhibits MRX functions at telomeres.

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