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On the mechanism of the insulin-glucose interactions.

Authors
Type
Published Article
Journal
Acta diabetologica latina
Publication Date
Volume
16
Issue
2
Pages
169–174
Identifiers
PMID: 484165
Source
Medline
License
Unknown

Abstract

Analysis of the course of D-glucose binding to insulin has shown that the mechanism of glucose-insulin interaction is a cooperative process. Binding of D-glucose molecules to insulin is facilitated by the dissociation of insulin aggregates caused by insulin-glucose interaction. Thus, insulin behaves as a system with strong positive cooperativity. The results have been treated in accordance with theories for interactions coupled to association equilibria. The data obtained support the idea that insulin monomers are the active species responsible for insulin action.

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