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The mechanism of the angiotensin-converting enzyme inhibitor quinapril is not related to bradykinin level in heart tissue.

Authors
  • Barthelemy, Christiane
  • Eurin, Joelle
  • Philippe Lechat
  • Masson, Francoise
  • Cortines, Micheline
  • Mougenot, Nathalie
  • Soualmia, Hayet
  • Carayon, Alain
Type
Published Article
Journal
JAMA Dermatology
Publisher
American Medical Association
Publication Date
June 2002
Volume
23
Issue
6
Pages
1161–1169
Identifiers
PMID: 12126746
Source
USPC - SET - SVS
License
Unknown

Abstract

In order to examine the effect of the angiotensin-converting enzyme inhibitor (ACEi) quinapril, we performed a sensitive and specific radioimmunoassay (RIA) to quantify bradykinin, BK-(1-9), in heart and kidney tissues. The BK-(1-9) level was unaffected in the heart of sham and water-deprived rats treated for 2h with quinapril (10mg/kg), but was significantly higher in the kidneys in the two groups. In these conditions, circulating and tissue angiotensin II (Ang II) levels were significantly decreased by quinapril. Moreover, our results indicated that acute treatment with this dose of quinapril induced kinin-mediated effects which were not related to its action on bradykinin degradation in rat hearts.

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