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Mechanism of anergy in AIDS and malnutrition.

Authors
Type
Published Article
Journal
Medical Hypotheses
0306-9877
Publisher
Elsevier
Publication Date
Volume
36
Issue
2
Pages
114–117
Identifiers
PMID: 1779913
Source
Medline

Abstract

Human immunodeficiency virus, the retrovirus associated with acquired immunodeficiency syndrome, is known to deplete CD4+ helper cells and reduce CD8+ cytotoxic cell activity, resulting in impaired cell-mediated immunity and a 'state of anergy'. This leads to dissemination of micro-organisms that are normally held dormant in the host by the cell-mediated immune system. Malnutrition also leads to depletion of CD4+ helper cells and decreases CD8+ cytotoxic cells leading to impaired cell-mediated immunity and 'state of anergy'. Clinical situation can worsen when the two conditions co-exist.

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