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Mechanically induced development and maturation of human intestinal organoids in vivo

Authors
  • Poling, Holly M.1
  • Wu, David2
  • Brown, Nicole1
  • Baker, Michael3
  • Hausfeld, Taylor A.1
  • Huynh, Nhan4, 5
  • Chaffron, Samuel6
  • Dunn, James C. Y.4, 5, 7, 8
  • Hogan, Simon P.2
  • Wells, James M.9, 10
  • Helmrath, Michael A.1
  • Mahe, Maxime M.1, 11
  • 1 Cincinnati Children’s Hospital Medical Center, Division of Pediatric General and Thoracic Surgery, Cincinnati, OH, USA , Cincinnati (United States)
  • 2 Cincinnati Children’s Hospital Medical Center, Department of Allergy and Immunology, Cincinnati, OH, USA , Cincinnati (United States)
  • 3 Dartmouth–Hitchcock Medical Center, Department of Pathology, Lebanon, NH, USA , Lebanon (United States)
  • 4 University of California, Los Angeles, Department of Bioengineering, Los Angeles, CA, USA , Los Angeles (United States)
  • 5 University of California, Los Angeles, Department of Surgery, Los Angeles, CA, USA , Los Angeles (United States)
  • 6 CNRS, University of Nantes, CNRS UMR 6004-LS2N, Nantes, France , Nantes (France)
  • 7 Stanford University, Department of Bioengineering, Stanford, CA, USA , Stanford (United States)
  • 8 Stanford University, Department of Pediatric Surgery, Stanford, CA, USA , Stanford (United States)
  • 9 Cincinnati Children’s Hospital Medical Center, Division of Developmental Biology, Cincinnati, OH, USA , Cincinnati (United States)
  • 10 Cincinnati Children’s Hospital Medical Center, Division of Endocrinology, Cincinnati, OH, USA , Cincinnati (United States)
  • 11 INSERM, University of Nantes, INSERM UMR 1235–TENS, Nantes, France , Nantes (France)
Type
Published Article
Journal
Nature Biomedical Engineering
Publisher
Nature Publishing Group UK
Publication Date
Jun 04, 2018
Volume
2
Issue
6
Pages
429–442
Identifiers
DOI: 10.1038/s41551-018-0243-9
Source
Springer Nature
License
Yellow

Abstract

Uniaxial strain provided by compressed nitinol springs incorporated in human intestinal organoids transplanted into the mouse mesentery enhances organoid growth and maturation, and improves the similarity of the organoids to native human intestine.

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