Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Measuring cerebral atrophy and white matter hyperintensity burden to predict the rate of cognitive decline in Alzheimer disease.

Authors
Type
Published Article
Journal
Archives of Neurology
0003-9942
Publisher
American Medical Association
Publication Date
Volume
65
Issue
9
Pages
1202–1208
Identifiers
DOI: 10.1001/archneur.65.9.1202
PMID: 18779424
Source
Medline
License
Unknown

Abstract

Both degree of cerebral atrophy and severity of WMH are associated with the rapidity of cognitive decline in AD. Atrophy and WMH may have a synergistic effect on future decline in AD, such that patients with a high degree of both have a particularly precipitous cognitive course. These findings lend further support to the hypothesis that cerebrovascular pathological abnormalities contribute to the clinical syndrome of AD.

Statistics

Seen <100 times