Measures of immunologic and inflammatory responses in vitro in rheumatoid patients treated with methotrexate.
- Published Article
The Journal of rheumatology
- Publication Date
Apr 01, 1986
We examined the effects of low dose parenteral methotrexate (MTX) on immunologic and inflammatory responses of potential importance in the pathogenesis of rheumatoid arthritis. Only 2 significant changes were noted: the number of esterase positive cells in the peripheral blood decreased, and the uptake of tritiated thymidine by incubated peripheral blood mononuclear cells fell markedly. These changes were present 48 h after an injection of MTX, before decreased disease activity became clinically apparent. We therefore conclude that they were direct effects of the drug itself.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3723494