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Measures of immunologic and inflammatory responses in vitro in rheumatoid patients treated with methotrexate.

Authors
Type
Published Article
Journal
The Journal of Rheumatology
0315-162X
Publisher
The Journal of Rheumatology
Publication Date
Volume
13
Issue
2
Pages
294–296
Identifiers
PMID: 3723494
Source
Medline

Abstract

We examined the effects of low dose parenteral methotrexate (MTX) on immunologic and inflammatory responses of potential importance in the pathogenesis of rheumatoid arthritis. Only 2 significant changes were noted: the number of esterase positive cells in the peripheral blood decreased, and the uptake of tritiated thymidine by incubated peripheral blood mononuclear cells fell markedly. These changes were present 48 h after an injection of MTX, before decreased disease activity became clinically apparent. We therefore conclude that they were direct effects of the drug itself.

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