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The measurement of internal pressure of ampoules and its application to commercial products.

Authors
Type
Published Article
Journal
The Journal of pharmacy and pharmacology
Publication Date
Volume
42
Issue
12
Pages
867–869
Identifiers
PMID: 1983150
Source
Medline

Abstract

This paper reports a method for determining the internal pressures of ampoules, from the head space and the change in volume on opening, as measured by displacement of water. Using this method, internal pressures of commercial ampoules were shown to be lower than atmospheric pressure. For example, the ratio of internal pressure to atmospheric pressure in a commercial ampoule of 5 mL distilled water was 0.884 at room temperature (23 degrees C).

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