Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry.
- Published Article
- Publication Date
Nov 01, 1979
The plasma concentration of the prostacyclin (PGI2) hydration product 6-oxo-PGF1 alpha has been assayed by stable isotope dilution GC-MS in six normal volunteers infused with increasing doses of PGI2 intravenously. The predosing levels of 6-oxo-PGF1 alpha ranged between 114 and 266 pg/ml. Infusion of PGI2 increased 6-oxo-PGF1 alpha concentration in plasma but the increments were lower than expected suggesting less conversion of the PGI2 to 6-oxo-PGF1 alpha at high infusion rates.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/396578