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Measurement of 6-oxo-PGF1 alpha in human plasma using gas chromatography-mass spectrometry.

Authors
  • Hensby, C N
  • Fitzgerald, G A
  • Friedman, L A
  • Lewis, P J
  • Dollery, C T
Type
Published Article
Journal
Prostaglandins
Publication Date
Nov 01, 1979
Volume
18
Issue
5
Pages
731–736
Identifiers
PMID: 396578
Source
Medline
License
Unknown

Abstract

The plasma concentration of the prostacyclin (PGI2) hydration product 6-oxo-PGF1 alpha has been assayed by stable isotope dilution GC-MS in six normal volunteers infused with increasing doses of PGI2 intravenously. The predosing levels of 6-oxo-PGF1 alpha ranged between 114 and 266 pg/ml. Infusion of PGI2 increased 6-oxo-PGF1 alpha concentration in plasma but the increments were lower than expected suggesting less conversion of the PGI2 to 6-oxo-PGF1 alpha at high infusion rates.

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