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Mean platelet volume and platelet distribution width serve as prognostic biomarkers in skull base chordoma: a retrospective study

Authors
  • Li, Mingxuan1
  • Bai, Jiwei2
  • Wang, Shuai1
  • Zhai, Yixuan3
  • Zhang, Shuheng1, 4
  • Li, Chuzhong1
  • Du, Jiang5
  • Zhang, Yazhuo1, 2, 6, 7, 2
  • 1 Beijing Neurosurgical Institute, Capital Medical University, No.119 South Fourth Ring West Road, Fengtai District, Beijing, 100070, China , Beijing (China)
  • 2 Capital Medical University, Beijing, China , Beijing (China)
  • 3 The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China , Zhengzhou (China)
  • 4 Department of Neurosurgery, Anshan Central Hospital, Anshan, China , Anshan (China)
  • 5 Beijing Neurosurgical Institute, Capital Medical University, Beijing, China , Beijing (China)
  • 6 Beijing Institute for Brain Disorders Brain Tumor Center, Beijing, China , Beijing (China)
  • 7 China National Clinical Research Center for Neurological Diseases, Beijing, China , Beijing (China)
Type
Published Article
Journal
BMC Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 12, 2020
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12885-020-07497-7
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundIncreasing studies have demonstrated that activated platelets play an essential role in tumour progression. However, the level and prognostic role of platelet indices in chordoma patients remain unclear. The aim of the current study was to characterize the prognostic performance of platelet count (PLT), mean platelet volume (MPV) and platelet distribution width (PDW) in skull base chordoma patients.Methods187 primary skull base chordoma patients between January 2008 and September 2014 were enrolled in this retrospective study. The optimal cut-off values were determined by X-tile software, and the correlations between PLT, MPV, PDW and clinicopathological features were further analysed. Kaplan-Meier curve and Cox regression analysis were used for survival analysis.ResultsThe values of preoperative PTL, MPV and PDW ranged from 104 to 501 × 109/L, 6.7 to 14.2 fl, and 7.8 to 26.2%, respectively. Elevated PLT was associated with larger tumour volume (p = 0.002). Kaplan-Meier survival analysis revealed that increased MPV and PDW were associated with shorter overall survival (p = 0.022 and 0.008, respectively). Importantly, multivariate Cox analysis demonstrated that elevated PDW was an independent unfavourable predictive factor for overall survival (hazard ratio (HR), 2.154, 95% confidence interval (CI), 1.258–3.688, p = 0.005).ConclusionsOur data show that elevated MPV and PDW are associated with poor outcomes in skull base chordoma and that PDW may be helpful to identify patients with high risk.

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