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MDR1 and ERCC1 expression predict outcome of patients with locally advanced bladder cancer receiving adjuvant chemotherapy.

Authors
  • Hoffmann, Andreas-Claudius
  • Wild, Peter
  • Leicht, Christina
  • Bertz, Simone
  • Danenberg, Kathleen D
  • Danenberg, Peter V
  • Stöhr, Robert
  • Stöckle, Michael
  • Lehmann, Jan
  • Schuler, Martin
  • Hartmann, Arndt
Type
Published Article
Journal
Neoplasia
Publisher
Elsevier
Publication Date
Aug 01, 2010
Volume
12
Issue
8
Pages
628–636
Identifiers
PMID: 20689757
Source
Medline
License
Unknown

Abstract

High MDR1 and ERCC1 gene expressions are associated with inferior outcome after cisplatin-based adjuvant chemotherapy for locally advanced bladder cancer. Prospective studies are warranted to define a role for MDR1 and ERCC1 analysis in individualizing multimodality treatment in locally advanced bladder cancer.

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