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MDR-1 gene polymorphisms in steroid-responsive versus steroid-resistant nephrotic syndrome in children.

Authors
  • Jafar, Tabrez1
  • Prasad, Narayan
  • Agarwal, Vikas
  • Mahdi, Abbas
  • Gupta, Amit
  • Sharma, Raj K
  • Negi, Mahendra Pal Singh
  • Agrawal, Suraksha
  • 1 Department of Medical Genetics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. , (India)
Type
Published Article
Journal
Nephrology Dialysis Transplantation
Publisher
Oxford University Press
Publication Date
Dec 01, 2011
Volume
26
Issue
12
Pages
3968–3974
Identifiers
DOI: 10.1093/ndt/gfr150
PMID: 21460357
Source
Medline
License
Unknown

Abstract

Patients with NS carrying homozygous mutants of single nucleotide polymorphism (SNP) G2677T/A are prone to develop SRNS. The synergistic effect of mutant genotypes of SNPs G2677T/A and C3435T in different combinations increase the risk of developing steroid resistance in patients with NS.

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