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MC4R deficiency in pigs results in hyperphagia and ultimately hepatic steatosis without high-fat diet.

Authors
  • Hao, Haiyang1
  • Lin, Rutao2
  • Li, Zhiyuan1
  • Shi, Wenshu3
  • Huang, Tongtong1
  • Niu, Jianqin1
  • Han, Jianyong4
  • Li, Qiuyan5
  • 1 State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. , (China)
  • 2 College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China. , (China)
  • 3 College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. , (China)
  • 4 State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. Electronic address: [email protected] , (China)
  • 5 State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, 100193, China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Biochemical and Biophysical Research Communications
Publisher
Elsevier
Publication Date
Dec 10, 2019
Volume
520
Issue
3
Pages
651–656
Identifiers
DOI: 10.1016/j.bbrc.2019.08.016
PMID: 31629472
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Melanocortin 4 receptor (MC4R)-deficient mice had been used for several years to study human nonalcoholic steatohepatitis (NASH). However, although liver pathologic and biochemical indicators have been examined, mice models do not always faithfully display the phenotype of the human disease. In this study, we investigated the MC4R knockout phenotype in miniature pigs. We found that pigs lacking MC4R exhibited hyperorexia, insulin resistance, hyperinsulinemia, disordered lipid metabolism and their livers accumulated significant amounts of fat. We have shown that deletion of MC4R results in hyperphagia and increased body fat, ultimately leading to hepatic steatosis without atherogenic diet. Copyright © 2019. Published by Elsevier Inc.

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