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The maximum possible amount of drug in rapidly separating microneedles.

Authors
  • Zhu, Dan Dan1
  • Zhang, Xiao Peng1
  • Shen, Chang Bing2
  • Cui, Yong3
  • Guo, Xin Dong4
  • 1 Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China. , (China)
  • 2 Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, People's Republic of China. , (China)
  • 3 Department of Dermatology, China-Japan Friendship Hospital, East Street Cherry Park, Chaoyang District, Beijing, 100029, People's Republic of China. [email protected] , (China)
  • 4 Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China. [email protected] , (China)
Type
Published Article
Journal
Drug delivery and translational research
Publication Date
Dec 01, 2019
Volume
9
Issue
6
Pages
1133–1142
Identifiers
DOI: 10.1007/s13346-019-00658-7
PMID: 31292933
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

There is an increasing concern on the drug loading capacity of microneedles (MNs) to meet higher drug dosage requirement. The present study describes the fabrication of modified rapidly separating polyvinyl alcohol (PVA)-based MNs (RS-P-MNs) with high drug loading using a mechanical agitation process. The drugs encapsulated within the PVA polymer gel by mechanical agitation served as an encapsulating agent for drugs that provide a high drug loading capacity and also release of drugs in a controlled manner. The various parameters such as microscopic analysis, atomic force microscopy (AFM), drug loading, drug delivery efficiency, mechanical test, skin penetration ability, and in vitro and in vivo analyses indicate the great potential of the RS-P-MNs. The maximum drug loading capacity of RS-P-MNs was measured to be approximately 900 ng per microneedle, which was almost a hundred times than the traditional drug encapsulating mode. The in vitro and in vivo results suggested that the controlled release of drugs is due to the encapsulating mode (mechanical agitation) of drugs. The prepared RS-P-MNs with high drug loading in this study provided a gentle and controlled release of drugs instead of the robust release of drugs from traditional MNs. Graphical abstract.

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