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Maximal Fat Oxidation During Exercise Is Already Impaired in Pre-pubescent Children With Type 1 Diabetes Mellitus

Authors
  • Fel, Solenne1
  • Rochette, Emmanuelle1, 2, 3
  • Walther, Guillaume4
  • Echaubard, Stéphane1
  • Pereira, Bruno5
  • Merlin, Etienne1, 2, 6
  • Terral, Daniel1
  • Duché, Pascale3
  • 1 Pédiatrie Générale et Multidisciplinaire, CHU Clermont-Ferrand, Clermont-Ferrand , (France)
  • 2 INSERM, CIC 1405, Unité CRECHE, Université Clermont Auvergne, Clermont-Ferrand , (France)
  • 3 Laboratoire IAPS, Université de Toulon, Toulon , (France)
  • 4 LaPEC, Avignon Université, Avignon , (France)
  • 5 Délégation de la Recherche Clinique et Innovations, CHU Clermont-Ferrand, Clermont-Ferrand , (France)
  • 6 INRA, UMR 1019 UNH, ECREIN, Université Clermont Auvergne, Clermont-Ferrand , (France)
Type
Published Article
Journal
Frontiers in Physiology
Publisher
Frontiers Media SA
Publication Date
Apr 09, 2021
Volume
12
Identifiers
DOI: 10.3389/fphys.2021.664211
Source
Frontiers
Keywords
Disciplines
  • Physiology
  • Original Research
License
Green

Abstract

Objective: We evaluated substrate utilization during submaximal exercise, together with glycemic responses and hormonal counter-regulation to exercise, in children with type 1 diabetes mellitus (T1DM). Methods: Twelve pre-pubescent children with T1DM and 12 healthy children were matched by sex and age. Participants completed a submaximal incremental exercise test to determine their fat and carbohydrate oxidation rates by indirect calorimetry. Levels of glycemia, glucagon, cortisol, growth hormone, noradrenaline, adrenaline, and insulin were monitored until 120 min post-exercise. Results: Absolute peak oxygen uptake (VO2 peak) was significantly lower in the children with T1DM than in the healthy controls (1131.4 ± 102.5 vs. 1383.0 ± 316.6 ml.min−1, p = 0.03). Overall carbohydrate and lipid oxidation rates were the same in the two groups, but for exercise intensities, higher than 50% of VO2 peak, fat oxidation rate was significantly lower in the children with T1DM. The absolute maximal lipid oxidation rate was significantly lower in the T1DM children (158.1 ± 31.6 vs. 205.4 ± 42.1 mg.min−1, p = 0.005), and they reached a significantly lower exercise power than the healthy controls (26.4 ± 1.2 vs. 35.4 ± 3.3 W, p = 0.03). Blood glucose responses to exercise were negatively correlated with pre-exercise blood glucose concentrations (r = −0.67; p = 0.03). Conclusion: Metabolic and hormonal responses during sub-maximal exercise are impaired in young children with T1DM.

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