Affordable Access

deepdyve-link
Publisher Website

Matrix Degradation in Human Immunodeficiency Virus Type 1-Associated Tuberculosis and Tuberculosis Immune Reconstitution Inflammatory Syndrome: A Prospective Observational Study.

Authors
  • Walker, Naomi F1, 2, 3, 4
  • Wilkinson, Katalin A1, 3, 5
  • Meintjes, Graeme1, 3
  • Tezera, Liku B6
  • Goliath, Rene1
  • Peyper, Janique M7, 8
  • Tadokera, Rebecca1, 9
  • Opondo, Charles10
  • Coussens, Anna K1
  • Wilkinson, Robert J1, 3, 5, 11
  • Friedland, Jon S2
  • Elkington, Paul T2, 6
  • 1 Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, South Africa. , (South Africa)
  • 2 Infectious Diseases and Immunity, and Imperial College Wellcome Trust Centre for Global Health, Imperial College London, United Kingdom. , (United Kingdom)
  • 3 Department of Medicine, University of Cape Town, Observatory, South Africa. , (South Africa)
  • 4 Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
  • 5 Francis Crick Institute, London, United Kingdom , (United Kingdom)
  • 6 National Institute for Health Research Respiratory Biomedical Research Unit, Clinical and Experimental Sciences Academic Unit, Faculty of Medicine, University of Southampton, United Kingdom. , (United Kingdom)
  • 7 Applied Proteomics and Chemical Biology Group, Department of Integrative Biomedical Sciences.
  • 8 Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory.
  • 9 HIV/AIDS, Sexually Transmitted Infections and Tuberculosis Programme, Human Sciences Research Council, Cape Town, South Africa. , (South Africa)
  • 10 Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, UK.
  • 11 Department of Medicine, Imperial College London, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Jul 01, 2017
Volume
65
Issue
1
Pages
121–132
Identifiers
DOI: 10.1093/cid/cix231
PMID: 28475709
Source
Medline
Keywords
License
Unknown

Abstract

MMP activity in TB differs by HIV-1 status and compartment, and releases matrix degradation products. Matrix turnover in HIV-1-infected patients is increased before and during TB-IRIS, informing novel diagnostic strategies. MMP inhibition is a potential host-directed therapy strategy for prevention and treatment of TB-IRIS.

Report this publication

Statistics

Seen <100 times