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Matrix-assisted peptide synthesis on nanoparticles.

Authors
  • Khandadash, Raz
  • Machtey, Victoria
  • Weiss, Aryeh
  • Byk, Gerardo
Type
Published Article
Journal
Journal of Peptide Science
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2014
Volume
20
Issue
9
Pages
675–679
Identifiers
DOI: 10.1002/psc.2664
PMID: 24889925
Source
Medline
Keywords
License
Unknown

Abstract

We report a new method for multistep peptide synthesis on polymeric nanoparticles of differing sizes. Polymeric nanoparticles were functionalized via their temporary embedment into a magnetic inorganic matrix that allows multistep peptide synthesis. The matrix is removed at the end of the process for obtaining nanoparticles functionalized with peptides. The matrix-assisted synthesis on nanoparticles was proved by generating various biologically relevant peptides.

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