Affordable Access

deepdyve-link
Publisher Website

Mathematical modeling of Notch dynamics in Drosophila neural development.

Authors
  • Yasugi, Tetsuo1
  • Sato, Makoto1, 2
  • 1 Mathematical Neuroscience Unit, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan. , (Japan)
  • 2 Laboratory of Developmental Neurobiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. , (Japan)
Type
Published Article
Journal
Fly
Publisher
Landes Bioscience
Publication Date
Dec 01, 2022
Volume
16
Issue
1
Pages
24–36
Identifiers
DOI: 10.1080/19336934.2021.1953363
PMID: 34609265
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Notch signalling is a well-conserved signalling pathway that regulates cell fate through cell-cell communication. A typical feature of Notch signalling is 'lateral inhibition', whereby two neighbouring cells of equivalent state of differentiation acquire different cell fates. Recently, mathematical and computational approaches have addressed the Notch dynamics in Drosophila neural development. Typical examples of lateral inhibition are observed in the specification of neural stem cells in the embryo and sensory organ precursors in the thorax. In eye disc development, Notch signalling cooperates with other signalling pathways to define the evenly spaced positioning of the photoreceptor cells. The interplay between Notch and epidermal growth factor receptor signalling regulates the timing of neural stem cell differentiation in the optic lobe. In this review, we summarize the theoretical studies that have been conducted to elucidate the Notch dynamics in these systems and discuss the advantages of combining mathematical models with biological experiments.

Report this publication

Statistics

Seen <100 times