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A mathematical model for the immunosenescence.

Authors
  • Luciani, F
  • Turchetti, G
  • Franceschi, C
  • Valensin, S
Type
Published Article
Journal
Rivista di biologia
Publication Date
Jan 01, 2001
Volume
94
Issue
2
Pages
305–318
Identifiers
PMID: 11702654
Source
Medline
License
Unknown

Abstract

We propose a model for the dynamics of the immune system by considering the subpopulations of virgin and memory T lymphocytes on a time scale corresponding to the human life span. In the deterministic balance equation we introduce a fluctuating term in order to take into account the chronic antigenic stress. Starting from the hypothesis that the depletion of virgin cells with cytotoxic properties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves.

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