A mathematical model for the immunosenescence.
- Published Article
Rivista di biologia
- Publication Date
Jan 01, 2001
We propose a model for the dynamics of the immune system by considering the subpopulations of virgin and memory T lymphocytes on a time scale corresponding to the human life span. In the deterministic balance equation we introduce a fluctuating term in order to take into account the chronic antigenic stress. Starting from the hypothesis that the depletion of virgin cells with cytotoxic properties (CD8+) is a mortality marker, the model provides survival curves quite similar to the demographic curves.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/11702654