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Mathematical analysis of multienzyme systems. I. Modelling of the glycolysis of human erythrocytes.

Authors
  • Rapoport, T A
  • Heinrich, R
Type
Published Article
Journal
Biosystems
Publisher
Elsevier
Publication Date
Jul 01, 1975
Volume
7
Issue
1
Pages
120–129
Identifiers
PMID: 168932
Source
Medline
Language
English
License
Unknown

Abstract

A mathematical model for the glycolysis of human erythrocytes is presented which takes into account ATP-synthesis and -consumption. A set of three differential equations describes the steady states and the time-dependent changes of the metabolite concentrations under blood storage conditions. For a given parameter combination there are in general three stationary points of the system, one of which is unstable. At a low ATP-need the ATP-level is relatively constant for variations in the rate constant of the ATP-consuming processes. Above a critical level of the energy consumption the system breaks down. An important role of the 2.3P2G-bypass of the erythrocytes is its action as an "energy buffer", wasting ATP in case of ATP-overproduction and producing ATP in case of underproduction. A parameter combination consistent with the data on the isolated enzymes was found which gives a good agreement of theoretical predictions with the measured metabolite concentrations. Under blood preservation conditions the difference of the rates of ATP-production and -consumption is the most important factor for a high ATP-level over long periods.

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