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Maternal Weight Differences Do Not Explain Ethnic Differences in Biochemical Screening

Authors
  • Bryant-Greenwood, Peter K.
  • O’Brien, Joseph E.
  • Huang, Xiaohua
  • Yaron, Yuval
  • Ayoub, Mazin
  • Johnson, Mark P.
  • Evans, Mark I.
Type
Published Article
Journal
Fetal Diagnosis and Therapy
Publisher
S. Karger AG
Publication Date
Feb 01, 1998
Volume
13
Issue
1
Pages
46–48
Identifiers
DOI: 10.1159/000020801
Source
Karger
Keywords
License
Green
External links

Abstract

In previous work, we and others have shown that serum levels of α-fetoprotein, human chorionic gonadotropin, and estriol vary among the four commonly defined racial/ethnic groups seen in the United States: white, African-American, Asian, and Hispanic. We have suggested that better sensitivity and specificity could improve screening sensitivity and specificity. However, it has been argued that systematic weight differences among the groups could explain the variation. We evaluated the results from 208,257 patients having screening and found systematic weight differences. However, these differences were not as large as the racial/ethnic differences, showing that weight does not fully explain the discrepancy, and, therefore, four separate data bases give more accurate results.

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