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Maternal obesity enhances oocyte chromosome abnormalities associated with aging.

Authors
  • Yun, Yan1, 2
  • Wei, Zijie2
  • Hunter, Neil3, 4, 5, 6
  • 1 Howard Hughes Medical Institute, University of California, Davis, Davis, CA, USA.
  • 2 Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA.
  • 3 Howard Hughes Medical Institute, University of California, Davis, Davis, CA, USA. [email protected]
  • 4 Department of Microbiology & Molecular Genetics, University of California, Davis, Davis, CA, USA. [email protected]
  • 5 Department of Molecular & Cellular Biology, University of California, Davis, Davis, CA, USA. [email protected]
  • 6 Department of Cell Biology & Human Anatomy, University of California, Davis, Davis, CA, USA. [email protected]
Type
Published Article
Journal
Chromosoma
Publisher
Springer-Verlag
Publication Date
Sep 01, 2019
Volume
128
Issue
3
Pages
413–421
Identifiers
DOI: 10.1007/s00412-019-00716-6
PMID: 31286204
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Obesity is increasing globally, and maternal obesity has adverse effects on pregnancy outcomes and the long-term health of offspring. Maternal obesity has been associated with pregnancy failure through impaired oogenesis and embryogenesis. However, whether maternal obesity causes chromosome abnormalities in oocytes has remained unclear. Here we show that chromosome abnormalities are increased in the oocytes of obese mice fed a high-fat diet and identify weakened sister-chromatid cohesion as the likely cause. Numbers of full-grown follicles retrieved from obese mice were the same as controls and the efficiency of in vitro oocyte maturation remained high. However, chromosome abnormalities presenting in both metaphase-I and metaphase-II were elevated, most prominently the premature separation of sister chromatids. Weakened sister-chromatid cohesion in oocytes from obese mice was manifested both as the terminalization of chiasmata in metaphase-I and as increased separation of sister centromeres in metaphase II. Obesity-associated abnormalities were elevated in older mice implying that maternal obesity exacerbates the deterioration of cohesion seen with advancing age.

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