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Maternal hypothyroxinemia during pregnancy and growth of the fetal and infant head.

Authors
Type
Published Article
Journal
Reproductive sciences (Thousand Oaks, Calif.)
Publication Date
Volume
19
Issue
12
Pages
1315–1322
Identifiers
DOI: 10.1177/1933719112450338
PMID: 22878528
Source
Medline

Abstract

Severe maternal thyroid dysfunction during pregnancy affects fetal brain growth and corticogenesis. This study focused on the effect of maternal hypothyroxinemia during early pregnancy on growth of the fetal and infant head. In a population-based birth cohort, we assessed thyroid status in early pregnancy (median 13.4, 90% range 10.8-17.2), in 4894 women, and measured the prenatal and postnatal head size of their children at 5 time points. Hypothyroxinemia was defined as normal thyroid-stimulating hormone levels and free thyroxine-4 concentrations below the 10th percentile. Statistical analysis was performed using linear generalized estimating equation. Maternal hypothyroxinemia was associated with larger fetal and infant head size (overall estimate β: 1.38, 95% confidence interval 0.56; 2.19, P = .001). In conclusion, in the general population, even small variations in maternal thyroid function during pregnancy may affect the developing head of the young child.

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