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Maternal and Cord Blood Adiponectin Concentrations in Small for Gestational Age: A Meta-Analysis

Authors
  • Goto, Eita
Type
Published Article
Journal
Annals of Nutrition and Metabolism
Publisher
S. Karger AG
Publication Date
Dec 22, 2017
Volume
72
Issue
1
Pages
57–64
Identifiers
DOI: 10.1159/000485748
PMID: 29275407
Source
Karger
Keywords
License
Green
External links

Abstract

Background: Adiponectin, which may have a growth-promoting effect through its insulin-sensitizing action, is thought to play a key role in fetal growth. This study was performed to determine whether maternal and/or cord blood adiponectin concentrations differ between small for gestational age (SGA) and healthy controls. Methods: Databases were searched to identify good quality English language studies providing the number of SGA and healthy controls, and the means and standard deviations of maternal or cord blood adiponectin concentration in both groups. A meta-analysis was performed to summarize the standardized mean differences (SMDs) in maternal and cord blood adiponectin concentrations between SGA and healthy controls. Results: There was no statistically significant difference in maternal blood adiponectin concentration between SGA and healthy controls (n = 8, p = 0.951). However, cord blood adiponectin concentration was significantly lower in SGA than in healthy controls (n = 6, p = 0.028), and the effect was large (i.e., SMD >0.7). Conclusions: Maternal blood adiponectin concentration is not low in SGA compared with healthy controls. However, SGA shows lower cord blood adiponectin concentration than healthy controls.

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