Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep.
- Authors
- Type
- Published Article
- Journal
- American Journal of Obstetrics and Gynecology
- Publisher
- Elsevier
- Publication Date
- Jun 01, 2011
- Volume
- 204
- Issue
- 6
- Identifiers
- DOI: 10.1016/j.ajog.2011.02.035
- PMID: 21481833
- Source
- Medline
- License
- Unknown
Abstract
Maternal macrolide administration achieves subtherapeutic concentrations in AF or fetal plasma, whereas a single IA injection achieves therapeutic concentrations in AF but not in maternal-fetal circulations. Combined maternal and single IA administration of macrolides may be a more effective regimen for treatment of intrauterine, but not fetal, infection.