Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep.

Jeffrey A Keelan; Ilias Nitsos; Masatoshi Saito; Gabrielle C Musk; Matthew W Kemp; Matthew Timmins; Shaofu Li; Nobuo Yaegashi; John P Newnham

doi:10.1016/j.ajog.2011.02.035

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Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep.

Authors

Keelan, Jeffrey A
Nitsos, Ilias
Saito, Masatoshi
Musk, Gabrielle C
Kemp, Matthew W
Timmins, Matthew
Li, Shaofu
Yaegashi, Nobuo
Newnham, John P

Type

Published Article

Journal

American Journal of Obstetrics and Gynecology

Publisher

Elsevier

Publication Date

Jun 01, 2011

Volume

204

Issue

6

Identifiers

DOI: 10.1016/j.ajog.2011.02.035

PMID: 21481833

Source

Medline

License

Unknown

Abstract

Maternal macrolide administration achieves subtherapeutic concentrations in AF or fetal plasma, whereas a single IA injection achieves therapeutic concentrations in AF but not in maternal-fetal circulations. Combined maternal and single IA administration of macrolides may be a more effective regimen for treatment of intrauterine, but not fetal, infection.

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. This record was last updated on 07/04/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM. The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/21481833

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