Affordable Access

deepdyve-link deepdyve-link
Publisher Website

Maternal-amniotic-fetal distribution of macrolide antibiotics following intravenous, intramuscular, and intraamniotic administration in late pregnant sheep.

Authors
  • Keelan, Jeffrey A
  • Nitsos, Ilias
  • Saito, Masatoshi
  • Musk, Gabrielle C
  • Kemp, Matthew W
  • Timmins, Matthew
  • Li, Shaofu
  • Yaegashi, Nobuo
  • Newnham, John P
Type
Published Article
Journal
American Journal of Obstetrics and Gynecology
Publisher
Elsevier
Publication Date
Jun 01, 2011
Volume
204
Issue
6
Identifiers
DOI: 10.1016/j.ajog.2011.02.035
PMID: 21481833
Source
Medline
License
Unknown

Abstract

Maternal macrolide administration achieves subtherapeutic concentrations in AF or fetal plasma, whereas a single IA injection achieves therapeutic concentrations in AF but not in maternal-fetal circulations. Combined maternal and single IA administration of macrolides may be a more effective regimen for treatment of intrauterine, but not fetal, infection.

Report this publication

Statistics

Seen <100 times