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Markers of platelet activation and thrombin generation

Authors
  • Becker, Richard C.1
  • 1 University of Massachusetts Medical School and Thrombosis Research Center, UMass-Memorial Medical Center, 55 Lake Avenue, Worcester, MA, 01655 , Worcester
Type
Published Article
Journal
Cardiovascular Toxicology
Publisher
Humana Press
Publication Date
Jun 01, 2001
Volume
1
Issue
2
Pages
141–145
Identifiers
DOI: 10.1385/CT:1:2:141
Source
Springer Nature
Keywords
License
Yellow

Abstract

The laboratory assessment of platelet biology and coagulation has traditionally focused on abnormalities, congenital or acquired, that provide insights for understanding hemostatic defects, unexplained bleeding, and pharmacologic titration of compounds designed to attenuate thrombotic potential. Because atherosclerotic vascular disease is associated with thrombotic events and there exists a clear link between atherosclerosis, inflammation, and thrombosis, the development of markers that have pathobiologic, prognostic, and treatment-related relevance has taken on a role of considerable importance.

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