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Markers of Endothelial Cells in Normal and Pathological Conditions

Authors
  • Goncharov, N. V.1, 2
  • Popova, P. I.3
  • Avdonin, P. P.4
  • Kudryavtsev, I. V.5, 6
  • Serebryakova, M. K.5
  • Korf, E. A.1
  • Avdonin, P. V.4
  • 1 Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, 194223, Russia , St. Petersburg (Russia)
  • 2 Research Institute of Hygiene, Occupational Pathology and Human Ecology, p.o. Kuz’molovskii, Leningrad oblast, 188663, Russia , p.o. Kuz’molovskii (Russia)
  • 3 City Polyclinic no. 19, St. Petersburg, 142238, Russia , St. Petersburg (Russia)
  • 4 Koltzov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334, Russia , Moscow (Russia)
  • 5 Institute of Experimental Medicine, St. Petersburg, 197376, Russia , St. Petersburg (Russia)
  • 6 Far-East Federal University, Vladivostok, 690091, Russia , Vladivostok (Russia)
Type
Published Article
Journal
Biochemistry (Moscow) Supplement Series A Membrane and Cell Biology
Publisher
Pleiades Publishing
Publication Date
Jul 01, 2020
Volume
14
Issue
3
Pages
167–183
Identifiers
DOI: 10.1134/S1990747819030140
Source
Springer Nature
Keywords
License
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Abstract

AbstractEndothelial cells (ECs) line the blood vessels and lymphatic vessels, as well as heart chambers, forming the border between the tissues, on the one hand, and blood or lymph, on the other. Such a strategic position of the endothelium determines its most important functional role in the regulation of vascular tone, hemostasis, and inflammatory processes. The damaged endothelium can be both a cause and a consequence of many diseases. The state of the endothelium is indicated by the phenotype of these cells, represented mainly by (trans)membrane markers (surface antigens). This review defines endothelial markers, provides a list of them, and considers the mechanisms of their expression and the role of the endothelium in certain pathological conditions.

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