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Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries.

Authors
  • van der Giessen, W J
  • Lincoff, A M
  • Schwartz, R S
  • van Beusekom, H M
  • Serruys, P W
  • Holmes, D R Jr
  • Ellis, S G
  • Topol, E J
Type
Published Article
Journal
Circulation
Publication Date
Oct 01, 1996
Volume
94
Issue
7
Pages
1690–1697
Identifiers
PMID: 8840862
Source
Medline
License
Unknown

Abstract

An array of both biodegradable and nonbiodegradable polymers has been demonstrated to induce a marked inflammatory reaction within the coronary artery with subsequent neointimal thickening, which was not expected on the basis of in vitro tests. The observed tissue response may be attributable to a combination of parent polymer compound, biodegradation products, and possibly implant geometry.

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