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Marine sponge-derived/inspired drugs and their applications in drug delivery systems.

Authors
  • Ramanjooloo, Avin1, 2
  • Andersen, Raymond J3
  • Bhaw-Luximon, Archana2
  • 1 Mauritius Oceanography Institute, Avenue des Anchois, Morcellement de Chazal, Albion, Mauritius. , (Mauritius)
  • 2 Biomaterials, Drug Delivery & Nanotechnology Unit, Centre for Biomedical & Biomaterials Research, MSIRI Building, University of Mauritius, 80837 Réduit, Mauritius. , (Mauritius)
  • 3 Departments of Chemistry & Earth, Ocean, & Atmospheric Sciences, University of British Columbia, Vancouver, BC V6T 1Z1, Canada. , (Canada)
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
Feb 10, 2021
Identifiers
DOI: 10.4155/fmc-2020-0123
PMID: 33565317
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Oceans harbor a vast biodiversity not represented in terrestrial habitats. Marine sponges have been the richest source of marine natural products reported to date, and sponge-derived natural products have served as inspiration for the development of several drugs in clinical use. However, many promising sponge-derived drug candidates have been stalled in clinical trials due to lack of efficacy, off-target toxicity, metabolic instability or poor pharmacokinetics. One possible solution to this high clinical failure rate is to design drug delivery systems that deliver drugs in a controlled and specific manner. This review critically analyzes drugs/drug candidates inspired by sponge natural products and the potential use of drug delivery systems as a new strategy to enhance the success rate for translation into clinical use.

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