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Marine and plant-based n-3 PUFA and atherosclerotic cardiovascular disease.

Authors
  • Bork, Christian S1
  • Venø, Stine K1
  • Lasota, Anne N2
  • Lundbye-Christensen, Søren3, 4
  • Schmidt, Erik B1, 3
  • 1 Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. , (Denmark)
  • 2 Department of Vascular Surgery, Aalborg University Hospital, Aalborg, Denmark. , (Denmark)
  • 3 Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. , (Denmark)
  • 4 Unit of Clinical Biostatistics, Aalborg University Hospital, Aalborg, Denmark. , (Denmark)
Type
Published Article
Journal
Proceedings of The Nutrition Society
Publisher
Cambridge University Press
Publication Date
Feb 01, 2020
Volume
79
Issue
1
Pages
22–29
Identifiers
DOI: 10.1017/S0029665119000582
PMID: 30982476
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

n-3 PUFA may exert favourable effects on several processes that may inhibit the atherosclerotic process. However, the role of n-3 PUFA in lowering the risk of atherosclerotic CVD (ASCVD) has been fiercely debated. In the present paper, we summarise the main findings from previous follow-up studies of intake and studies using adipose tissue as an objective biomarker to investigate exposure to n-3 PUFA in relation to ASCVD risk and discuss some perspectives for further research. The majority of previous studies investigating intake of marine- and plant-based n-3 PUFA have focused on CHD while other ASCVD such as ischaemic stroke and peripheral artery disease have been less studied. However, recent data from Danish Diet, Cancer and Health cohort suggest that marine n-3 PUFA may be inversely associated with risk of myocardial infarction, ischaemic stroke and peripheral arterial disease caused by atherosclerosis. The effect of the plant-derived n-3 PUFA α-linolenic acid on ASCVD is less clear and several gaps in the literature remain to be explored.

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