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Marine natural product libraries for high-throughput screening and rapid drug discovery.

Authors
  • Bugni, Tim S1
  • Richards, Burt
  • Bhoite, Leen
  • Cimbora, Daniel
  • Harper, Mary Kay
  • Ireland, Chris M
  • 1 Department of Medicinal Chemistry, University of Utah, 30 S. 2000 E. RM 307, Salt Lake City, Utah 84112, USA.
Type
Published Article
Journal
Journal of Natural Products
Publisher
American Chemical Society
Publication Date
June 2008
Volume
71
Issue
6
Pages
1095–1098
Identifiers
DOI: 10.1021/np800184g
PMID: 18505284
Source
Medline
License
Unknown

Abstract

There is a need for diverse molecular libraries for phenotype-selective and high-throughput screening. To make marine natural products (MNPs) more amenable to newer screening paradigms and shorten discovery time lines, we have created an MNP library characterized online using MS. To test the potential of the library, we screened a subset of the library in a phenotype-selective screen to identify compounds that inhibited the growth of BRCA2-deficient cells.

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